The role of extracellular matrix in the exercise training-specific remodeling of white adipose tissues

2011 Fiscal Year Final Research Report

• Project/Area Number: 22700655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: SAKURAI Takuya 杏林大学, 医学部, 助教 (20353477)
• Research Collaborator: OHNO Hideki 杏林大学, 医学部, 教授 (00133819) ; KIZAKI Takako 杏林大学, 医学部, 教授 (00322446) ; OGASAWARA Jyunetsu 杏林大学, 医学部, 助教 (20415110)
• Project Period (FY): 2010 – 2011
• Keywords: 脂肪組織 / 運動トレーニング / 肥満 / 糖尿病 / リモデリング / 細胞外マトリックス

Research Abstract

White adipose tissues(WAT) are remodeled due to exercise training(TR). The extracellular matrix(ECM), which encloses adipocytes, is thought to play an important role in remodeling of WAT. In the present study, therefore, the role of ECM in TR and obesity-specific remodeling of WAT was investigated. Expression of the gene for the dermatopontin(Dpt), which is one of the ECM, in WAT is higher in obese mice than in lean mice. TR definitely attenuated such obesity-induced Dpt gene expression in WAT. Moreover, TR enhanced expression of the ECM receptor integrinα1 gene in WAT. These results suggest that Dpt and integrinα1 are considered to be implicated in remodeling of WAT by TR.

Research Products

• [Journal Article] Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases (2012)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Sumitani, Y., Takahashi, K., Ishida, H., Miyazaki, H., Saitoh, D., Haga, S., Izawa, T. & Ohno, H.
  • Journal Title: Environ. Health Prev. Med Volume: 17(In press)
  • Peer Reviewed
• [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus (2012)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Radak, Z. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(In press)
  • Peer Reviewed
• [Journal Article] Effect of exercise on HIF-1 and VEGF signaling (2012)
  • Author(s): Ohno, H., Shirato, K., Sakurai, T., Ogasawara, J., Sumitani, Y., Sato, S., Imaizumi, K., Ishida, H. & Kizaki, T
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 5-16
  • Peer Reviewed
• [Journal Article] Copy number variations due to large genomic deletion in x. linked chronic granulomatous disease (2012)
  • Author(s): Arai, T., Oh-Ishi, T., Yamamoto, H., Nunoi, H., Kamizono, J., Uehara, M., Kubota, T., Sakurai, T., Kizaki, T. & Ohno, H
  • Journal Title: PLoS One Volume: 7 Pages: e27782
  • DOI: DOI:10.1371/journal.pone.0027782
  • Peer Reviewed
• [Journal Article] The effects of exercise on macrophage function (2012)
  • Author(s): Kizaki, T., Sato, S., Sakurai, T., Ogasawara, J., Imaizumi, K., Izawa, T., Nagasawa, J., Saitoh, D., Haga, S. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(In press)
  • Peer Reviewed
• [Journal Article] Effect of physical exercise on lipolysis in white adipocytes (2012)
  • Author(s): Ogasawara, J., Sakurai, T., Kizaki, T., Takahashi, K., Sumitani, Y., Ishida, H., Izawa, T., Toshinai, K. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(In press)
  • Peer Reviewed
• [Journal Article] Involvement of leucine zipper transcription factor-like protein 1(Lztfl1) in the attenuation of cognitive impairment by exercise training (2011)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Oh-ishi, S., Haga, S. & Ohno, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 416 Pages: 125-129
  • DOI: DOI:10.1016/j.bbrc.2011.11.008
  • Peer Reviewed
• [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages (2011)
  • Author(s): Kizaki, T., Maegawa, T., Sakurai, T., Ogasawara, J., Ookawara, T., Oh-ishi, S., Izawa, T., Haga, S. & Ohno, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 413 Pages: 454-459
  • DOI: DOI:10.1016/j.bbrc.2011.08.117
  • Peer Reviewed
• [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats (2011)
  • Author(s): Hatano, D., Ogasawara, J., Endoh, S., Sakurai, T., Nomura, S., Kizaki, T., Ohno, H., Komabayashi, T. & Izawa, T
  • Journal Title: Scand. J. Med. Sci Volume: 21 Pages: 115-121
  • DOI: DOI:10.1111/j.1600-0838.2010.01176.x
  • Peer Reviewed
• [Journal Article] Comparison of the effect of Oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes (2011)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. & Ohno, H
  • Journal Title: Phytother Res Volume: 25 Pages: 467-471
  • DOI: DOI:10.1002/ptr.3296
  • Peer Reviewed
• [Journal Article] 食細胞の機能と低酸素環境 (2011)
  • Author(s): 大野秀樹、白土健、櫻井拓也、小笠原準悦、石橋義永、芳賀脩光、木崎節子
  • Journal Title: 臨床免疫・アレルギー科 Volume: 55 Pages: 239-246
• [Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes (2010)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H., Tanno, M. & Ohno, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 402 Pages: 554-559
  • DOI: DOI:10.1016/j.bbrc.2010.10.082
  • Peer Reviewed
• [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes (2010)
  • Author(s): Ogasawara, J., Nomura, S., Rahman, N., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H., Haga, S. & Ohno, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 400 Pages: 134-139
  • DOI: DOI:10.1016/j.bbrc.2010.08.026
  • Peer Reviewed
• [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue (2010)
  • Author(s): Sakurai, T., Endo, S., Hatano, D., Ogasawara, J., Kizaki, T., Oh-ishi, S., Izawa, T., Ishida, H. & Ohno, H
  • Journal Title: Acta Physiol(Oxf) Volume: 200 Pages: 325-338
  • DOI: DOI:10.1111/j.1748-1708.2010.02159.x
  • Peer Reviewed
• [Journal Article] Effect of exercise training on adipocyte size-dependent expression of leptin and adiponectin (2010)
  • Author(s): Miyazaki, S., Izawa, T., Ogasawara, J., Sakurai, T., Nomura, S., Kizaki, T., Ohno, H. & Komabayashi, T
  • Journal Title: Life Sci Volume: 86 Pages: 691-698
  • DOI: DOI:10.1016/j.lfs.2010.03.004
  • Peer Reviewed
• [Journal Article] 低圧・低酸素環境が引き起こす酸化ストレスとオリゴノールの抗酸化効果 (2010)
  • Author(s): 長澤純一、杉山康塚、内丸仁、笹尾真美、高野宏二、野口いづみ、鈴木康弘、北舘健太郎、芳賀脩光、前川剛輝、櫻井拓也、小笠原準悦、木崎節子、大野秀樹
  • Journal Title: 登山医学 Volume: 30 Pages: 118-124
  • Peer Reviewed
• [Presentation] Oligonolは神経細胞において小胞体ストレス減弱作用をもつ (2012)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20120324-26
• [Presentation] オリジナリティあふれる衛生学を～社会医学と実験医学のクロストーク～ (2012)
  • Author(s): 櫻井拓也
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20120324-26
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化シグナルを促進する (2012)
  • Author(s): 小笠原準悦, ほか
  • Place of Presentation: 京都
  • Year and Date: 20120324-26
• [Presentation] Oligonolは神経細胞において小胞体ストレスを減弱させる (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第9回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 20111119-20
• [Presentation] Preventive effects of Oligonol on cognitive impairment in senescence. accelerated mice and identification of its molecular target in hippocampus (2011)
  • Author(s): Sakurai, T., et al.
  • Organizer: 第19回統合医療機能性食品国際会議
  • Place of Presentation: 札幌
  • Year and Date: 20111015-16
• [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 20110916-18
• [Presentation] 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体Oligonolの効果 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第21回体力・栄養・免疫学会大会
  • Place of Presentation: 東京
  • Year and Date: 20110827-28
• [Presentation] 運動は老化促進モデルマウスの認知機能障害を予防する (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第19回日本運動生理学会大会
  • Place of Presentation: 徳島
  • Year and Date: 20110825-26
• [Presentation] The lipolytic activity in adipocytes differs between normal and high fat diet micevia changes in the trafficking ofss_2-adrenergic receptor (2011)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20110328-30
• [Presentation] 脂肪組織をプローブとした運動トレーニングおよびサプリメント摂取による肥満・生活習慣病の予防・改善効果 (2011)
  • Author(s): 櫻井拓也
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 20110325-28
• [Presentation] 肥満抑制効果を有するOligonolによる脂肪分解反応の調節機構の解明 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 20110325-28
• [Presentation] 運動は骨格筋から褐色脂肪細胞への分化を活性化するか (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第40回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2011-11-19
• [Presentation] 運動およびOligonolの摂取は老化促進モデルマウスの認知機能障害を予防する (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-25
• [Presentation] 老化促進モデルマウスの認知機能障害に対するOligonolの予防効果 (2010)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第8回日本予防医学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 20101211-12
• [Presentation] 老化促進モデルマウスの認知機能障害に対する運動トレーニングの予防効果 (2010)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 市川
  • Year and Date: 20100916-18
• [Presentation] 持久的トレーニングによる脂肪細胞のATG発現の変化と調節メカニズム (2010)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第18回日本運動生理学会大会
  • Place of Presentation: 鹿児島
  • Year and Date: 20100731-0801
• [Presentation] Both Oligonol and exercise have preventive effects on cognitive impairment in senescence-accelerated mice (2010)
  • Author(s): Sakurai, T., et al.
  • Organizer: 18th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
  • Year and Date: 20100724-25
• [Presentation] Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via activation of the ERK1/2 pathway (2010)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 11th International Congress on Obesity ICO 2010
  • Place of Presentation: Stockholm
  • Year and Date: 20100711-15
• [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Triglyceride Lipase(ATGL)の役割 (2010)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第80回日本衛生学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20100509-11
• [Presentation] 運動および新規低分子化ポリフェノールOligonolによる脂肪組織酸化ストレス軽減効果 (2010)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第80回日本衛生学会総会:連携研究会酸化ストレス研究会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 20100509-11
• [Presentation] 新規低分子化ポリフェノール(Oligonol)による脂肪分解反応の調節メカニズム (2010)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第39回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2010-11-20
• [Book] 機能性食品素材と運動療法-生活習慣病予防と運動機能維持向上を目指して- (2012)
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• [Book] 脂肪組織のエクササイズバイオロジー1冊まるごと脂肪組織と運動の話 (2011)
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  • Total Pages: 23-130
  • Publisher: ナップ
• [Book] Proceedings 19th International Congress on Nutritionand Integrative Medicine (2011)
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  • Total Pages: 113-116
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• [Book] 公益財団法人中冨健康科学振興財団第22回研究助成業績集平成23年版 (2011)
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• [Book] 明治安田厚生事業団第27回健康医科学研究助成論文集平成22年度 (2010)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 87-96
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  • Author(s): 大野秀樹, ほか
  • Total Pages: 516-517
  • Publisher: 朝倉書店
• [Book] 運動生理学のニューエビデンス (2010)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 381-388
  • Publisher: 真興交易(株)医書出版部
• [Book] 『日本臨床』:2010年増刊肥満症[第2版]-基礎・臨床研究の進歩- (2010)
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  • Total Pages: 272-276
  • Publisher: 日本臨床社