2011 Fiscal Year Final Research Report
Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α
| Project/Area Number |
22700661
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Kyoritsu Women's Junior College (2011)
Nippon Medical School (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 運動 / 神経新生 / 海馬 / ストレス / 血管新生 |
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| Research Abstract |
The purpose of this study was to investigate whether exercise-induced enhancement of hippocampal neurogenesis and prevention of depression is attributed to VEGF signaling pathway of hippocampus dependently on hepatic VEGF. The preset findings suggested that regular exercise prevents stress-induced onset of depression via VEGF signaling pathway of hippocampus independently of exercise-induced increase of hepatic VEGF.
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