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2011 Fiscal Year Final Research Report

Research on the role of microRNA in skeletal muscle atrophy

Research Project

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Project/Area Number 22700669
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research Institution地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所) (2011)
Gifu International Institute of Biotechnology (2010)

Principal Investigator

FUJITA Yasunori  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)

Project Period (FY) 2010 – 2011
Keywords筋萎縮 / microRNA
Research Abstract

In an attempt toreveal the molecular mechanism of skeletal muscle atrophy, we identified microRNAs(miRNAs) that were related to atrophy by microarray analysisand investigatedtheirfunctionin mousemyoblast C2C12 cells. Resultssuggested that mmu-miR-148apromotesmuscleatrophy of differentiated C2C12 cells. It is necessary to verify its usefulness as a molecular targetfor the treatment andprevention ofskeletal muscle atrophy by more detailed research.

  • Research Products

    (4 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] MicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation2012

    • Author(s)
      Yasunori Fujita, Nanako Hamada, Toshio Kojima, Aya Kitamoto, Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito
    • Journal Title

      Neurochem Int

      Volume: 60 Pages: 743-750

    • DOI

      DOI:10.1016/j.neuint.2012.03.010

    • Peer Reviewed
  • [Journal Article] MiR-148a attenuates paclitaxel-resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression2010

    • Author(s)
      Yasunori Fujita, Keitaro Kojima, Riyako Ohhashi, Nanako Hamada, Yoshinori Nozawa, Aya Kitamoto, Akira Sato, Shinji Kondo, Toshio Kojima, Takashi Deguchi, Masafumi Ito
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 19076-84

    • DOI

      DOI:10.1074/jbc.M109.079525

    • Peer Reviewed
  • [Presentation] MiR-130a attenuates paclitaxel resistance of drug-resistant prostate cancer PC3 cells through post-transcriptional regulation of MSK1 expression2011

    • Author(s)
      Yasunori Fujita, Toshio Kojima, Keita Nakane, Taku Kato, Keitaro Kojima, Nanako Hamada, Riyako Ohhashi, Takashi DeguchiYoshinori Nozawa, Masafumi Ito
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
  • [Presentation] MicroRNA expression profiling of NGF-treated PC12 cells revealed critical roles of miR-221 in neuronal differentiation2011

    • Author(s)
      Nanako Hamada, Yasunori Fujita, Toshio Kojima, Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-13

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Published: 2013-07-31  

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