2011 Fiscal Year Final Research Report
Research on the role of microRNA in skeletal muscle atrophy
Project/Area Number |
22700669
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Sports science
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Research Institution | 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所) (2011) Gifu International Institute of Biotechnology (2010) |
Principal Investigator |
FUJITA Yasunori 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)
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Project Period (FY) |
2010 – 2011
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Keywords | 筋萎縮 / microRNA |
Research Abstract |
In an attempt toreveal the molecular mechanism of skeletal muscle atrophy, we identified microRNAs(miRNAs) that were related to atrophy by microarray analysisand investigatedtheirfunctionin mousemyoblast C2C12 cells. Resultssuggested that mmu-miR-148apromotesmuscleatrophy of differentiated C2C12 cells. It is necessary to verify its usefulness as a molecular targetfor the treatment andprevention ofskeletal muscle atrophy by more detailed research.
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[Journal Article] MiR-148a attenuates paclitaxel-resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression2010
Author(s)
Yasunori Fujita, Keitaro Kojima, Riyako Ohhashi, Nanako Hamada, Yoshinori Nozawa, Aya Kitamoto, Akira Sato, Shinji Kondo, Toshio Kojima, Takashi Deguchi, Masafumi Ito
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Journal Title
J Biol Chem
Volume: 285
Pages: 19076-84
DOI
Peer Reviewed
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