Association between subjective happiness and physical functions from perspectives of disease prevention and health promotion

2012 Fiscal Year Final Research Report

• Project/Area Number: 22700683
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: National Institute for Physiological Sciences (2011-2012); Fujita Health University (2010)
• Principal Investigator: MATSUNAGA Masahiro 生理学研究所, 大脳皮質機能研究系, 特任助教 (00533960)
• Project Period (FY): 2010 – 2012
• Keywords: 心身の健康

Research Abstract

The purposes of this study were to clarify the association between subjective happiness and physical functions, and to develop the effective strategy of health promotion. The present study indicated that sense of happiness was generated by function of the medial prefrontal cortex (mPFC), and has a role in suppressing the peripheral circulating pro-inflammatory cytokine levels. In addition, the present study indicated that the endocannabinoid system might be involved in the interaction between happiness and suppression of the cytokine secretion. The present findings could be applied to various scientific fields such as not only psychological but also clinical and pedagogical areas.

Research Products

• [Journal Article] Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers (2013)
  • Author(s): Ohira H, Osumi T, Matsunaga M, Yamakawa K
  • Journal Title: Neuro Endocrinol Lett Volume: 34(1) Pages: 47-51
  • Peer Reviewed
• [Journal Article] The structure of mindful brain (2012)
  • Author(s): Murakami H, Nakao T, Matsunaga M, Kasuya Y, Shinoda J, Yamada J, Ohira H
  • Journal Title: PLoS One Volume: 7(9)
  • Peer Reviewed
• [Journal Article] Psychological and physiological responses to odor-evoked autobiographic memory (2011)
  • Author(s): Matsunaga M, Isowa T, Yamakawa K, Kawanishi Y, Tsuboi H, Kaneko H, Sadato N, Oshida A, Katayama A, Kashiwagi M, Ohira H
  • Journal Title: Neuroendocrinology Letters 2011 Volume: 32(6) Pages: 774-780
  • Peer Reviewed
• [Journal Article] Chronic stress modulates neural and cardiovascular responses during reversal learning (2011)
  • Author(s): Ohira H, Matsunaga M, Kimura K, Murakami H, Osumi T, Isowa T, Fukuyama S, Shinoda J, Yamada J
  • Journal Title: Neuroscience 2011 Volume: 193 Pages: 193-204
  • Peer Reviewed
• [Journal Article] physiological responses to odor-evoked autobiographic memory (2011)
  • Author(s): Matsunaga M, Isowa T, Yamakawa K, Kawanishi Y, Tsuboi H, Kaneko H, Sadato N, Oshida A, Katayama A, Kashiwagi M, Ohira H
  • Journal Title: Activitas Nervosa Superior Rediviva 2011 Volume: 53(3) Pages: 114-120
  • Peer Reviewed
• [Journal Article] Association between perceived happiness levels and peripheral circulating pro-inflammatory cytokine levels in middle-aged adults in Japan (2011)
  • Author(s): Matsunaga M, Isowa T, Yamakawa K, Tsuboi H, Kawanishi Y, Kaneko H, Kasugai K, Yoneda M, Ohira H
  • Journal Title: Neuroendocrinology Letters 2011 Volume: 32(4) Pages: 458-463
  • Peer Reviewed
• [Journal Article] Perceived happiness level influences evocation of positive emotions (2011)
  • Author(s): Matsunaga M, Murakami H, Yamakawa K, Isowa T, Fukuyama S, Shinoda J, Yamada J, Ohira H
  • Journal Title: Natural Science 2011 Volume: 3(8) Pages: 723-727
  • Peer Reviewed
• [Journal Article] ラット急性ストレス負荷による大腸運動亢進に対する中枢オキシトシンの抑制作用 (2011)
  • Author(s): 金子宏,松永昌宏,坪井宏仁,川西陽子
  • Journal Title: 心身医学 Volume: 51(4) Pages: 323-328
• [Journal Article] 主観的幸福感に着目した心身相関の新展開 (2011)
  • Author(s): 松永昌宏,金子宏,坪井宏仁,川西陽子
  • Journal Title: 心身医学 Volume: 51(2) Pages: 135-140
• [Journal Article] Phasic heart rate responses for anticipated threat situations (2010)
  • Author(s): Murakami H, Matsunaga M, Ohira H
  • Journal Title: Int J Psychophysiol 2010 Volume: 77 Pages: 21-25
  • Peer Reviewed
• [Journal Article] Genetic variations in the serotonin transporter gene-linked polymorphic region influence attraction for a favorite person and the associated interactions between the central nervous and immune systems (2010)
  • Author(s): Matsunaga M, Murakami H, Yamakawa K, Isowa T, Kasugai K, Yoneda M, Kaneko H, Fukuyama S, Shinoda J, Yamada J, Ohira H
  • Journal Title: Neuroscience Letters 2010 Volume: 468 Pages: 211-215
  • Peer Reviewed
• [Presentation] Pavlovian-instrumental transfer by acute stress in decision making (2013)
  • Author(s): Yamakawa K, Matsunaga M, Isowa T, Ohira H
  • Organizer: 71st Annual Meeting of the American Psychosomatic Society
  • Year and Date: 2013-03-15
• [Presentation] Vagal tone modulates functional brain-body association (2013)
  • Author(s): Ohira H, Matsunaga M, Osumi T, Gidron Y
  • Organizer: 71st Annual Meeting of the American Psychosomatic Society
  • Year and Date: 2013-03-15
• [Presentation] 援助行動時の報酬系の賦活と共感特性の影響 (2013)
  • Author(s): 川道拓東、田邊宏樹、高橋陽香、吉原一 文、松永昌宏、菅原翔、牧田快、定藤規 弘
  • Organizer: 第2回社会神経科学研究会
  • Year and Date: 2013-01-31
• [Presentation] オキシトシン受容体遺伝子多型と自己罰傾向 (2013)
  • Author(s): 大坪庸介、松永昌宏、田中大貴、八木綾 乃、三船恒裕、小宮あすか
  • Organizer: 第2回社会神経科学研究会
  • Year and Date: 2013-01-31
• [Presentation] 急性ストレスによるPavlovian-instrumental transfer の検討 (2013)
  • Author(s): 山川香織、松永昌宏、磯和勅子、大平英樹
  • Organizer: 第2回社会神経科学研究会
  • Year and Date: 2013-01-31
• [Presentation] 社会脳システムが幸福感を決定する (2013)
  • Author(s): 松永昌宏、川道拓東、小池耕彦、吉原一文、吉田優美子、高橋陽香、中川恵理、定藤規弘
  • Organizer: 第2回社会神経科学研究会
  • Year and Date: 2013-01-31
• [Presentation] Study implication related to sense of acceptance: Key factor of social learning (2012)
  • Author(s): Kawamichi H, Yoshihara K, Kitada R, Matsunaga M, Sasaki A, Yoshida Y, Takahashi H, Sadato N
  • Organizer: Interantional Conference on Replacement of Neanderthals by Modern Humans: Testing Evolutionary Models of Learning
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-11-24
• [Presentation] 幸福感の神経基盤 (2012)
  • Author(s): 松永昌宏
  • Organizer: 日本心理学会第76回大会
  • Year and Date: 2012-09-11
• [Presentation] 内分泌・免疫活動と感情との関連 (2012)
  • Author(s): 松永昌宏
  • Organizer: 日本心理学会第76回大会
  • Year and Date: 2012-09-11
• [Presentation] 日本人における主観的幸福感・内側前頭前野活動・炎症性サイトカイン・主観的社会階層の関連 (2011)
  • Author(s): 松永昌宏、磯和勅子、山川香織、定藤規弘、大平英樹
  • Organizer: 第34回日本神経科学大会
  • Year and Date: 2011-09-17
• [Presentation] 生育家族の主観的社会階層と成人後の精神的健康との関連に関する研究 (2011)
  • Author(s): 松永昌宏、磯和勅子、山川香織、大平英樹、川西陽子、金子宏、坪井宏仁
  • Organizer: 第67回日本心身医学会中部地方会
  • Year and Date: 2011-05-14
• [Presentation] Modulation of neural cardiovascular, and immune reactivity to cognitive challenge by chronic job stress (2011)
  • Author(s): Ohira H, Matsunaga M, Kimura K, Murakami H, Osumi T
  • Organizer: American Psychosomatic Society 69th Annual Scientific Meeting, San Antonio
  • Place of Presentation: TX USA
  • Year and Date: 2011-03-12
• [Presentation] The level of cortisol induced by acute stress is related to decision making including risk (2011)
  • Author(s): Yamakawa K, Matsunaga M, Isowa T, Ohira H
  • Organizer: American Psychosomatic Society 69th Annual Scientific Meeting
  • Place of Presentation: TX USA
  • Year and Date: 2011-03-12
• [Presentation] Perceived happiness level influences evocation of positive emotions (2011)
  • Author(s): Matsunaga M, Kaneko H, Murakami H, Yamakawa K, Ohira H, Isowa T, Fukuyama S, Shinoda J, Yamada J
  • Organizer: American Psychosomatic Society 69th Annual Scientific Meeting
  • Place of Presentation: TX USA
  • Year and Date: 2011-03-11
• [Presentation] Frustrating stress aggravates dyspepsia symptom and gastric function in male volunteers (2011)
  • Author(s): Kaneko H, Matsunaga M, Iida A, Funaki Y, Yoneda M, Kasugai K
  • Organizer: American Psychosomatic Society 69th Annual Scientific Meeting
  • Place of Presentation: TX USA
  • Year and Date: 2011-03-10
• [Presentation] ポジティブ感情と健康との関連―脳と身体の機能的関連と遺伝子多型からの検討― (2010)
  • Author(s): 松永昌宏
  • Organizer: 日本人間行動進化学会第3回大会
  • Year and Date: 2010-12-05
• [Presentation] Role of central oxytocin in brain-gut interactions (2010)
  • Author(s): Matsunaga M, Kaneko H, Tsuboi H, Yoneda M, Kasugai K, Ohira H
  • Organizer: The 1st Asian Pacific Topic Conference
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-11-27
• [Presentation] 心理的ストレスの種類による液体 栄養剤投与後の胃収縮能に対する異なる 効果 (2010)
  • Author(s): 松永昌宏、金子宏、坪井宏仁、川西陽子、中出幸臣、春日井邦夫、米田政志、大平英樹
  • Organizer: 第3回J-FD 研究会
  • Year and Date: 2010-11-13
• [Presentation] 主観的幸福感とポジティブ感情喚起時の脳活動との関連 (2010)
  • Author(s): 松永昌宏、村上裕樹、山川香織、磯和勅子、大平英樹
  • Organizer: 日本心理学会第74回大会
  • Year and Date: 2010-09-20
• [Presentation] ポジティブ感情の心理生物学研究 (2010)
  • Author(s): 松永昌宏
  • Organizer: 日本健康心理学会 第23回大会
  • Year and Date: 2010-09-11
• [Presentation] 水回避ストレス負荷による腸管運動亢進に対する脳内オキシトシンの抑制作用 (2010)
  • Author(s): 松永昌宏、米田政志、春日井邦夫、大平英樹、坪井宏仁、金子宏
  • Organizer: 第33回日本神経科学大会
  • Year and Date: 2010-09-04
• [Presentation] 主観的幸福感に着目した心身相関の新展開 (2010)
  • Author(s): 松永昌宏、金子宏、坪井宏仁、川西陽子
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Year and Date: 2010-06-27
• [Presentation] ラット急性ストレス負荷による大腸運動亢進に対する中枢オキシトシンの抑制作用 (2010)
  • Author(s): 金子宏、松永昌宏、坪井宏仁、川西陽子
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Year and Date: 2010-06-26
• [Presentation] ドリンク摂取時の胃生理機能,血中ホル モン濃度変化に対する様々なストレス 負荷の影響 (2010)
  • Author(s): 松永昌宏、金子宏、坪井宏仁、川西陽子
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Year and Date: 2010-06-26
• [Presentation] 心拍変動に着目した バイオフィードバック療法の治療効果 に関する研究(第2 報) (2010)
  • Author(s): 松永昌宏、川西陽子、坪井宏仁、金子宏、竹内聡、榊原雅人
  • Organizer: 第65回日本心身医学会中部地方会
  • Year and Date: 2010-05-15
• [Presentation] Distinct gastric and hormonal responses toward various acute psychological stressors in rats (2010)
  • Author(s): Matsunaga M, Kaneko H, Tsuboi H, Kawanishi Y, Kasugai K, Yoneda M
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03