Research for the regulation of voluntary exercise and energy metabolism by appetite-regulating factors

2011 Fiscal Year Final Research Report

• Project/Area Number: 22700693
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: MAWATARI Kazuaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (40352372)
• Co-Investigator(Renkei-kenkyūsha): NAKAYA Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50136222) ; SAKAUE Hiroshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60372645) ; HARADA Nagamatsu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
• Project Period (FY): 2010 – 2011
• Keywords: 自発運動 / 摂食調節因子 / Ghrelin / 内臓脂肪 / 肥満

Research Abstract

We established a new animal model called SPORTS(Spontaneously-Running Tokushima-Shikoku) rats, which show high voluntary wheel running and low level of plasma total Ghrelin. The aim of this study was to investigate the in vivo effect of Ghrelin and Obestatin, which are appetite-regulating factors generated from prepro-Ghrelin, on voluntary wheel running and energy metabolism using the SPORTS animal model. We divided SPORTS rats into two groups, which were intramuscularly administrated Saline, Ghrelin, or Ghrelin+ Obestatin for six days(100. g/ kg BW/ day). Voluntary wheel running was significantly decreased in Ghrelin groups. Food intake, body weight, and abdominal visceral fat were significantly increased in Ghrelin groups. Obestatin suppressed Ghrelin-induced food intake, body weight, and abdominal visceral fat gains, but did not have any effect on voluntary wheel running. Our results suggest that Ghrelin and Obestatin may exert different pathway on the voluntary exercise or appetite. Some appetite-regulating factors may regulate voluntary exercise or energy metabolism.

Research Products

• [Journal Article] Telmisartan increases localization of glucose transporter 4 to the plasma membrane and increases glucose uptake via peroxisome proliferator-activated receptorγin 3T3-L1 adipocytes (2011)
  • Author(s): Hiroko Furukawa, Kazuaki Mawatari, Kei Koyama, Sonoko Yasui, Ran Morizumi, Takaaki Shimohata, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya
  • Journal Title: European Journal of Pharmacology Volume: Vol.660、No.2-3 Pages: 485-491
  • DOI: DOI:10.1016/j.ejphar.2011.04.008
  • Peer Reviewed
• [Journal Article] β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model (2010)
  • Author(s): Atsushi Hattori, Kazuaki Mawatari, Satomi Tsuzuki, Emiko Yoshioka, Satomi Toda, Masaki Yoshida, Sonoko Yasui, Hiroko Furukawa, Masaki Morishima, Katsushige Ono, Takamasa Ohnishi, Masayuki Nakano, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya
  • Journal Title: SPORTS. Obesity Volume: Vol.18、No.1 Pages: 48-54
  • DOI: DOI:10.1038/oby.2009.145
  • Peer Reviewed
• [Presentation] 自発運動制御におけるGhrelinの役割 (2011)
  • Author(s): 戸田聡美, 阪上浩, 谷口康子, 原田永勝, 馬渡一諭, 中屋豊, 志内哲也, 箕越靖彦
  • Organizer: 第14回日本病態栄養学会年次学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-01-16
• [Presentation] 自発運動制御におけるGhrelinの役割 (2010)
  • Author(s): 戸田聡美, 阪上浩, 谷口康子, 原田永勝, 馬渡一諭, 中屋豊, 志内哲也, 箕越靖彦
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(前橋市)
  • Year and Date: 2010-10-01
• [Presentation] 自発運動制御におけるGhrelinの役割 (2010)
  • Author(s): 戸田聡美, 阪上浩, 谷口康子, 志内哲也, 箕越靖彦, 原田永勝, 馬渡一諭, 中屋豊
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
  • Year and Date: 2010-05-28
• [Presentation] 自発運動制御におけるGhrelinの役割 (2010)
  • Author(s): 戸田聡美, 阪上浩, 谷口康子, 志内哲也, 箕越靖彦, 原田永勝, 馬渡一諭, 中屋豊
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティ徳島(徳島市)
  • Year and Date: 2010-05-23
• [Book] 栄養科学シリーズNEXT「応用栄養学」(第3版) (2012)
  • Author(s): 中坊幸弘, 木戸康博, 馬渡一諭(他24名)
  • Publisher: 講談社サイエンティフィック
• [Book] 栄養教育論演習 (2012)
  • Author(s): 岡崎光子, 饗場直美, 馬渡一諭(他13名)
  • Publisher: 建帛社