2011 Fiscal Year Final Research Report
Elucidation of the molecular mechanism of the functional carbohydrate on the postprandial metabolic change
| Project/Area Number |
22700696
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ARAI Hidekazu 静岡県立大学, 食品栄養科学部, 准教授 (60325256)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生活習慣病 / 食後高血糖 / 健康長寿 |
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| Research Abstract |
The postprandial hyperglycemia is associated with onset of metabolic syndrome greatly, and palatinose which is an isomer of the sucrose, was identified that it is the nourishment which can reduce hyperglycemia after a meal. However, the molecular mechanisms and substrate availability of palatinose ingestion are not clear. For the measurement of metabolic flexibility after the carbohydrate load test, the pattern of the metabolic response and the gene expression in the liver accorded with a slower blood glucose rising. This study suggested that exchange of sucrose for palatinose might results in a more favorable metabolic response, and might help to reduce disease such as diabetes mellitus.
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Research Products
(8 results)
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[Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor?2011
Author(s)
Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E.
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Journal Title
PLoS One
Volume: 6(8)
Pages: 22976
Peer Reviewed
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