2011 Fiscal Year Final Research Report
Proteomic analysis of nitrated proteins that change with aging and physical exercise in the brain
| Project/Area Number |
22700701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
UDA Munehiro 順天堂大学, 医学研究科, 博士研究員 (80549262)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 加齢 / 脳 / ニトロ化タンパク質 / ニトロトリプトプァン / 身体運動 |
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| Research Abstract |
We identified twelve 6-nitrotyptophan-containing proteins including several cytoskeletal proteins and glycolytic enzymes in the adult rat hippocampus and determined the position of nitrated tryptophan residue with significant ion score levels(p<0.05) in several proteins by proteomic analysis. In addition, the amount of 6-nitrotyptophan-containing protein tended to increase with age. On the other hand, physical exercise on the 12 months old rats did not induce much difference in the positive spots of anti-6-nitrotryptophan antibody.
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