2012 Fiscal Year Final Research Report
Effect of Skeletal Muscle-Drived Growth-Arrest Specific gene 6 on Phenotype Switching of Macrophages in Injured-Muscle in mice
| Project/Area Number |
22700704
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Kurashiki University of Science and the Arts |
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Principal Investigator |
SHIVA Daisuke 倉敷芸術科学大学, 生命科学部, 講師 (20515233)
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| Co-Investigator(Renkei-kenkyūsha) |
YANO Hiromi 川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
SUZUKI Katsuhiko 早稲田大学, スポーツ科学学術院, 准教授 (80344597)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Gas6 / マクロファージ / 骨格筋 |
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| Research Abstract |
This study examined that the Gas6 expression and regulation of macrophages functions by Gas6 in injured-skeletal muscle. In the results, it observed that injured-skeletal muscle by Cardiotoxin-induction was increased Gas6 expression compared with control muscle. In addition, it observed that Gas6 stimulation regulate macrophages phenotype.
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