2011 Fiscal Year Final Research Report
Effects of nutritional status on reproduction
| Project/Area Number |
22700749
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TSUTSUMI Rie 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80510172)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ゴナドトロピン / mTOR / kisspeptin / レプチン |
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| Research Abstract |
In this study, I demonstrated that the role of mTOR, which is well-known as a energy sensor of cells, and kisspeptin, is activated in downstream of mTOR, as a key modulator in the metabolic signaling and reproductive signaling. High-fat diet induced an increase of leptin level and decrease of mTOR activity and gonadotoropin secretion, whereas fasting also decreased gonadotoropin level and reproductive ability despite of leptin level was decreased.
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[Journal Article] Extracts of common buckwheat bran prevent sucrose digestion2011
Author(s)
Hosaka T, Nii Y, Tomotake H, Ito T, Tamanaha A, Yamasaka Y, Sasaga S, Edazawa K, Tsutsumi R, Shuto E, Okahisa N, Iwata S, Sakai T
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Journal Title
J Nutr Sci Vitaminol
Volume: (in press)
DOI
Peer Reviewed
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