2013 Fiscal Year Final Research Report
Effect of EPA on Cardiac Muscle Cells of Infants of Diabetic Mother Rats.
| Project/Area Number |
22700760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
KAWAHARADA Ritsuko (那須 律子) 高崎健康福祉大学, 健康福祉学部, 助教 (60383147)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 食と栄養 / 糖尿病 / 妊娠 |
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| Research Abstract |
We have previously reported that IDMs possessed abnormalities in insulin signaling and a fish oil-rich maternal diet improves cardiac Akt-related insulin signaling . In this study, we investigated the specific component in fish oil that was responsible for improving insulin signaling in primary cardiac muscle cells (PCMCs).
Pregnant diabetic rats were fed via gastric tube eicosapentaenoic acid(EPA group) or a control DDW (control). To examine changes in insulin signaling in the cardiac muscle in IDM, we isolated the heart and cultured PCMCs. The insulin signalling of the heart of IDM decreased, insulin resistance was induced. However, the impaired signalling has been improved by EPA medication during a diabetes mother's pregnancy. The protein of the heart of IDM exposed to hyperglycemia was saccharified highly.
The EPA in the fish oil may improve the impaired signaling pathway of the cardiac muscle of infants caused by a diabetic mother's hyperglycemia.
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