2011 Fiscal Year Final Research Report
Development of a novel functional food for overweight prevention based on the inhibition of ghrelin
| Project/Area Number |
22700772
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagasaki International University |
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Principal Investigator |
NODAKE Yuich 長崎国際大学, 薬学部・生化学研究室, 助教 (30332282)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAKIBARA Ryuzo 長崎国際大学, 薬学部・生化学研究室, 教授 (30127229)
FUKASAWA Masashi 長崎国際大学, 薬学部・生化学研究室, 准教授 (20238439)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 薬学 / 食品 / 蛋白質 / 生理活性 |
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| Research Abstract |
The binding mechanism of ghrelin that is a hunger-stimulating hormone to its receptor(GHS-R) has many unknown aspects. In this study, I tried to construct a comprehensive evaluation system of the interaction between both molecules. GHS-R cDNA was obtained from RT-PCR using rat stomach total RNA. Four extracellular regions of GHS-R that were important for binding to ghrelin were amplified by PCR based on the GHS-R cDNA and inserted into the expression vector. The interaction between recombinant extracellular region proteins fixed on a sensor chip and ghrelin was evaluated by surface plasmon resonance analysis.
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Research Products
(13 results)
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[Patent(Industrial Property Rights)] 新規乳酸菌とそれを用いた肝細胞保護剤(保護成分)
Inventor(s)
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Industrial Property Rights Holder
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Industrial Property Number
特許
