2011 Fiscal Year Final Research Report
The role of PIK3C3 in cell proliferation and tumor development
| Project/Area Number |
22700861
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Carcinogenesis
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| Research Institution | Akita University |
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Principal Investigator |
EGUCHI Satoshi 秋田大学, 大学院・医学系研究科, 助教 (70457117)
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| Project Period (FY) |
2010 – 2011
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| Keywords | イノシトールリン脂質 / ノックアウトマウス |
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| Research Abstract |
The role of PIK3C3 in cell proliferation and tumor development remains unclear. We generated knockout mice to analyze the physiological functions of PIK3C3. The deletion of PIK3C3 significantly suppressed cell proliferation and reduced the production of PI3P. In addition, PIK3C3 is necessary for starvation-induced autophagy. In adult mice, the ablation of PIK3C3 suppressed tumor development caused by Pten deletion in immune systems.
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[Journal Article] The PtdIns(3,4)P_2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death Nature2010
Author(s)
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T
Volume
465
Pages
497-501
Peer Reviewed
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