2011 Fiscal Year Final Research Report
The regulation of separase-securin in the maintenance of chromosomal stability, and its abnormality in cancer development
| Project/Area Number |
22700866
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Carcinogenesis
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| Research Institution | 公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010) |
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Principal Investigator |
KUMADA Kazuki 公益財団法人がん研究会, がん研究所実験病理部, 研究員 (10370149)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ゲノム不安定性 / 染色体分配 / プロテアーゼ / 形質転換 |
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| Research Abstract |
I found that auto-cleavage of separase, a protease that is inhibited by securin, is crucial for the proper regulation of separase activity, and the timely chromosome segregation. I also showed that a disturbance of the chromosome stability plays a role in the cell transformation induced by over-expression of securin. These data demonstrate the relationship between the function of separase-securin for the stable chromosome segregation and the tumor development.
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