2011 Fiscal Year Final Research Report
Molecular mechanisms by which increased glucose metabolism regulates signaling pathways in cancer
| Project/Area Number |
22700868
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 乳癌 / 糖代謝 / 3次元培養 |
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| Research Abstract |
In this study, using three dimensional culture of breast cancer cells, the principal investigator examined mechanisms by which increased glucose metabolism regulates signaling pathways in cancer cells. In particular, the PI focused on hexosamine biosynsethis pathway(HBP), which branches from glycolytic pathway, and found that the enzymes in HBP play fundamental roles in signaling activity and malignant phenotype in cancer cells. Moreover, O-GlcNAc modification of proteins, which is downstream of HBP, and the enzyme responsible for O-GlcNAc modification were also found to be essential. Target proteins modified with O-GlcNAc specifically in cancer cells were also identified, and the roles of the proteins and the modification are now under investigation.
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