2011 Fiscal Year Final Research Report
Elucidation of the regulation of INK4 locus and oncogenic mechanism by the dysregulation of INK4 locus.
| Project/Area Number |
22700880
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
KOTAKE Yojiro 浜松医科大学, 医学部, 助教 (90531963)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 細胞老化 / 転写制御 |
|---|
| Research Abstract |
INK4 locus encodes for three distinct tumor suppressors, p15, p16 and ARF, and is altered in an estimated 30-40% of human tumors. However, the mechanism of regulation of INK4 locus is unclear. In this study, we revealed that INK4 locus is regulated by Polycomb proteins, p53 and long noncoding RNA.
|
-
[Journal Article] Up-regulation of Cks1 and Skp2 with TNFα/NF-κB Signaling in Chronic Progressive Nephropathy2011
Author(s)
Sayuri Suzuki, Hirotaka Fukasawa, Taro Misaki, Akashi Togawa, Naro Ohashi, Kyoko Kitagawa, Yojiro Kotake, Hiroyuki Niida, Akira Hishida, Tatsuo Yamamoto and Kitagawa, Masatoshi
-
Journal Title
Genes to Cells
Volume: 16(11)
Pages: 1110-1120
-
-
[Journal Article] Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters2011
Author(s)
Tiffany Hung, Yulei Wang, Michael F. Lin, Ashley K. Koegel, Yojiro Kotake, Gavin Grant, Hugo M. Horlings, Nilay Shah, Christopher Umbricht, Pei Wang, Yu Wang, Benjamin Kong, Anita Langerod, Seung K. Kim, Marc van de Vijver, Saraswani Sukumar, Michael L. Whitfield, Manolis Kellis, Yue Xiong, David J. Wong and Howard Y. Chang
-
Journal Title
Nature Genetics
Volume: 43(7)
Pages: 621-629
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
