Involvement of organic anion transporter OAT1 on the chemo-sensitivity in renal cancer cells

2013 Fiscal Year Final Research Report

• Project/Area Number: 22700886
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: SUZUKI Eriko 東京農工大学, (連合)農学研究科(研究院), 助教 (00468513)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: がん細胞の特性

Research Abstract

Kidney cancer cells are usually resistant to chemotherapy, therefore chemotherapy has not been a standard treatment for kidney cancer. We focused on organic aniontransporter OAT1 expressed in renal glomerular endothelial cells and involved in resorption of general drug. Our study demonstrated that OAT1 expressing kidney cancer cells exhibits increased cell death concomitant with increased incorporation of anionic cancer drug including vincristine. In vivo imaging using EGFP-OAT1 overexpressing cells was first planned, however it was abandoned due to the absense of appropriate image-capturing system.