2011 Fiscal Year Final Research Report
Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cells
| Project/Area Number |
22700888
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | がん制御遺伝子 |
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| Research Abstract |
In this study, we sought to generate experimental platforms that help to understand the mechanism of how a mutation of BRCA1 tumor suppressor gene leads to the onset of human hereditary breast cancer. To this end, we used the technology of human somatic cell gene targeting in an attempt to perform the targeted correction of BRCA1 mutations in 2 cell lines derived from human hereditary breast cancers harboring homozygous BRCA1 mutations, as well as the targeted knock-in of 2 missense mutations into an immortalized human breast epithelial cell line MCF-10A which carries wild-type BRCA1.
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[Journal Article] Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells2011
Author(s)
Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 17773-8
DOI
Peer Reviewed
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[Journal Article] Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma2011
Author(s)
Sung CO, Kim SC, Karnan S, Karube K, Shin HJ, Nam DH, Suh YL, Kim SH, Kim JY, Kim SJ, Kim WS, Seto M, Ko YH
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Journal Title
Blood
Volume: 117
Pages: 1291-300
DOI
Peer Reviewed
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