2011 Fiscal Year Final Research Report
Functional analysis of mutant p53 on cancer invasion and metastasis using innovative in vivo imaging
| Project/Area Number |
22700890
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Nagoya City University (2011)
Japanese Foundation For Cancer Research (2010) |
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Principal Investigator |
INOUE Yasumichi 名古屋市立大学, 大学院・薬学研究科, 講師 (10450579)
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| Project Period (FY) |
2010 – 2011
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| Keywords | がん遺伝子 / シグナル伝達 |
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| Research Abstract |
p53 and TGF-βsignaling are well known as tumor suppressors which regulate cytostasis and apoptosis, whereas critical roles of mutant p53 and TGF-βsignaling in cancer metastasis have now emerged. In this project, we have demonstrated that proto-oncoprotein Ski, which is an important negative regulator of TGF-βsignaling, interacts with p53 and attenuates the biological functions of p53.Moreover, we have shown that Ski may prove to be an especially valuable therapeutic target. Also, we identified that histone methyltransferase SET8, which represses the biological functions of p53, also negatively regulates TGF-βsignaling.
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[Journal Article] ZSTK474, a specific PI3K inhibitor, induces G1 arrest of the cell cycle in vivo2012
Author(s)
Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A, Yamori T
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Journal Title
Eur J Cancer
Volume: 48
Pages: 936-943
Peer Reviewed
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