2011 Fiscal Year Final Research Report
Regulation of myeloid-derived suppressor cells in tumor microenvironment
| Project/Area Number |
22700894
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Tumor immunology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
WAKITA Daiko 北海道大学, 遺伝子病制御研究所, 助教 (30555404)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 免疫抑制 / MDSCs / IL-6 / 腫瘍内微小環境 / マクロファージ / 好中球 |
|---|
| Research Abstract |
To develop effective cancer immunotherapy, we investigated the regulation mechanisms of myeloid-derived suppressor cells(MDSCs), a immunosuppressive cells in tumor-bearing host. We found that MDSCs obtained suppressive activity by exposing to tumor microenvironment. Blocking of IL-6 signaling by anti-IL-6 receptor monoclonal antibody eliminated MDSCs and inhibited tumor growth via anti-tumor T-cell responses.
|
-
-
-
-
-
[Journal Article] Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive2011
Author(s)
Takahashi D, Azuma H, Sakai H, Sou K, Wakita D, Abe H, Fujihara N, Horinouchi H, Nishimura T, Kobayashi K, Ikeda H.
-
Journal Title
J Pharmacol Exp Ther
Volume: 337(1)
Pages: 42-9
URL
Peer Reviewed
-
-
[Journal Article] Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum Coronarium L2011
Author(s)
Tanaka S, Koizumi SI, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T.
-
Journal Title
Int Immunopharmacol
Volume: 11(2)
Pages: 226-32
URL
Peer Reviewed
-
[Journal Article] The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-γby DC or NK1. 1(+) cells in a TLR4-and TLR2-dependent manner2011
Author(s)
Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Wakita D, Chamoto K, Kitamura H, Nishimura T.
-
Journal Title
Cell Immunol
Volume: 266(2)
Pages: 135-42
URL
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
