2011 Fiscal Year Final Research Report
Comprehensive analysis of the genomic alterations of gastrointestinal cancers
| Project/Area Number |
22700903
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor diagnosis
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| Research Institution | Chiba University |
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Principal Investigator |
TADA Motohisa 千葉大学, 医学部・附属病院, 助教 (00554239)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ゲノム解析 |
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| Research Abstract |
We performed genome-wide analysis of 35 colorectal cancer (CC) and 34 gastric cancer (GC) cell lines for areas of DNA copy number changes and loss of heterozygosity (LOH) by the use of high-density single nucleotide polymorphism (SNP) array. The results from the array analysis were verified in 106 cancer tissues (CC ; 64, GC ; 42) by genomic quantitative real-time PCR and LOH analysis. Several never-detected genomic alterations were detected. Moreover, the overall survival of the patients with LOH with high frequency prolonged compared to that of the patients with LOH with low frequency.
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[Journal Article] Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer2010
Author(s)
Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Imazeki F, Yoshida H, Ogawa S, Yokosuka O, Omata M
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Journal Title
Cancer Sci
Volume: 101
Pages: 1261-1269
DOI
Peer Reviewed
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