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2011 Fiscal Year Final Research Report

The analysis of microRNA expression in lung adenocarcinomas with characteristic driver mutations and lung neuroendocrine carcinomas

Research Project

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Project/Area Number 22700909
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Tumor diagnosis
Research Institution公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010)

Principal Investigator

INAMURA Kentaro  公益財団法人がん研究会, がん研究所病理部, 研究員 (40442545)

Project Period (FY) 2010 – 2011
Keywords肺癌 / microRNA / 遺伝子変異 / 腺癌 / 小細胞癌
Research Abstract

Using microarrays, we identified the microRNAs characteristically expressed in EGFR mutated, KRAS mutated, and ALK translocated lung adenocarcinomas, respectively. Furthermore, we identified characteristic pathways for the microRNAs of EGFR mutated, KRAS mutated, and ALK translocated lung adenocarcinomas, respectively. On the other hand, small cell lung carcinomas(SCLCs) were classified into two groups(SCLC1 and SCLC2) by hierarchical clustering using microRNA microarray. SCLC1, which formed an independent cluster comprising only SCLCs, has a significant poorer prognosis than SCLC2, which clustered with lung adenocarcinomas(P=0.039). Further investigations, in silico and in vitro, are required to validate these results.

  • Research Products

    (28 results)

All 2012 2011 2010 Other

All Journal Article (8 results) Presentation (18 results) Book (1 results) Remarks (1 results)

  • [Journal Article] ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis2012

    • Author(s)
      Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H
    • Journal Title

      Lung Cancer

      Volume: 75(1) Pages: 119-25

    • DOI

      DOI:10.1016/j.lungcan.2011.05.028

  • [Journal Article] Diverse fusion patterns and heterogeneous clinicopathological features of renal cell carcinoma with t(6 ; 11) translocation2012

    • Author(s)
      Inamura K, Fujiwara M, Togashi Y, Nomura K, Mukai H, Fujii Y, Yamamoto S, Yonese J, Fukui I, Ishikawa Y
    • Journal Title

      Am J Surg Pathol

      Volume: 36(1) Pages: 35-42

    • DOI

      DOI:10.1097/PAS.0b013e3182293ec3

  • [Journal Article] Tumor Size is a Potential Predictor of the Response to Tyrosine Kinase Inhibitors in Renal Cell Cancer2011

    • Author(s)
      Yuasa T, Urakami S, Yamamoto S, Yonese J, Nakano K, Kodaira M, Takahashi S, Hatake K, Inamura K, Ishikawa Y, Fukui I
    • Journal Title

      Urology

      Volume: 77(4) Pages: 831-5

    • DOI

      DOI:10.1016/j.urology.2010.12.008

  • [Journal Article] Mixed squamous cell and glandular papilloma of the lung : A case study and literature review2011

    • Author(s)
      Inamura K, Kumasaka T, Furuta R, Shimada K, Hiyama N, Furuhata Y, Tanaka I, Takemura T
    • Journal Title

      Pathol Int

      Volume: 61(4) Pages: 252-8

    • DOI

      DOI:10.1111/j.1440-1827.2011.02659.x

  • [Journal Article] トランスクリプトームによる病態解析2011

    • Author(s)
      稲村健太郎,元井紀子,石川雄一
    • Journal Title

      病理と臨床

      Volume: 29 Pages: 522-8

  • [Journal Article] Is the Epidermal growth factor receptor status in lung cancers reflected in clinicopathologic features2010

    • Author(s)
      Inamura K, Ninomiya H, Ishikawa Y, Matsubara O.
    • Journal Title

      Arch Pathol Lab Med

      Volume: 134(1) Pages: 66-72

    • URL

      http://www.archivesofpathology.org/doi/full/10.1043/2008-0586-RAR1.1

  • [Journal Article] Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations2010

    • Author(s)
      Hiramatsu M, Ninomiya H, Inamura K, Nomura K, Takeuchi K, Satoh Y, Okumura S, Nakagawa K, Yamori T, Matsuura M, Morikawa T, Ishikawa Y
    • Journal Title

      Lung Cancer

      Volume: 70(1) Pages: 94-102

    • DOI

      DOI:10.1016/j.lungcan.2010.01.001

  • [Journal Article] Lung cancer progression and metastasis from the prognostic point of view2010

    • Author(s)
      Inamura K, Ishikawa Y
    • Journal Title

      Clin Exp Metastasis

      Volume: 27(6) Pages: 389-97

    • DOI

      DOI:10.1007/s10585-010-9313-4

  • [Presentation] Assessment of Invasion Degree of Small Sized Lung Cancer Using Intra-Operative Frozen Section2012

    • Author(s)
      Motoi N, et al
    • Organizer
      USCAP Annual meeting 2012
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20120317-23
  • [Presentation] 肺病変における術中迅速組織診断の有用性と限界2011

    • Author(s)
      元井紀子, 他
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      20111103-04
  • [Presentation] Genome-wide DNA methylation analysis of small cell lung cancer2011

    • Author(s)
      Saito Y, et al
    • Organizer
      70th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Year and Date
      20111003-05
  • [Presentation] Histology of ALK lung adenocarcinoma ; assessment of correlation between pathologic subtype and genotype2011

    • Author(s)
      Motoi N, et al
    • Organizer
      70th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Year and Date
      20111003-05
  • [Presentation] Evaluation of histologic accuracy on diagnosis and invasion of small-sized lung cancer using intra-operative frozen section2011

    • Author(s)
      Motoi N, et al
    • Organizer
      14th World conference on lung cancer
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      20110703-07
  • [Presentation] Morphologic diversity of ALK-related lung adenocarcinoma ; no correlation with chimeric variants2011

    • Author(s)
      Motoi N, et al
    • Organizer
      14th World conference on lung cancer
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      20110703-07
  • [Presentation] Assessment for underlying etiology of bronchioloalveolar carcinoma(BAC). Impacts of smoking habit and EGFR mutation2011

    • Author(s)
      Hiramatsu M, et al
    • Organizer
      14th World conference on lung cancer
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      20110703-07
  • [Presentation] TFEB転座腎癌:特徴的な臨床病理学的特徴を有する新規variant(2例)の発見2011

    • Author(s)
      稲村健太郎, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20110428-30
  • [Presentation] 肺腺癌における長鎖non-coding RNA MALAT-1の発現解析2011

    • Author(s)
      飯塚利彦, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20110428-30
  • [Presentation] 肺神経内分泌癌に対する高解像度SNPアレイを用いたゲノムインバランス解析2011

    • Author(s)
      苅田真, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20110428-30
  • [Presentation] TFEB translocation renal carcinoma : Two cases of novel isoforms with unique clinicopathological feature2011

    • Author(s)
      Inamura K, et al
    • Organizer
      The AACR 102nd Annual Meeting 2011
    • Place of Presentation
      Orlando, FL
    • Year and Date
      20110402-06
  • [Presentation] EML4-ALK陽性肺多形癌の1例2011

    • Author(s)
      佐藤征二郎, 他
    • Organizer
      第160回日本肺癌学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-12
  • [Presentation] 神経内分泌腫瘍の幹細胞性と細胞分化マーカーの発現2010

    • Author(s)
      元井紀子, 他
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      20101103-04
  • [Presentation] 肺神経内分泌癌に対する高解像度SNPアレイを用いたアレル解析2010

    • Author(s)
      苅田真, 他
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      20101103-04
  • [Presentation] 肺腺癌における喫煙と遺伝子変異・ゲノムコピー数の関連について2010

    • Author(s)
      二宮浩範, 他
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      20101103-04
  • [Presentation] miRNA発現プロファイリングによる予後良好な肺小細胞癌の同定2010

    • Author(s)
      大場岳彦, 他
    • Organizer
      第99日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20100427-29
  • [Presentation] 肺腺癌の相互排他的遺伝子異常と臨床病理組織像2010

    • Author(s)
      稲村健太郎, 他
    • Organizer
      第99日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20100427-29
  • [Presentation] 若年者多発肺癌で、両肺腫瘍に異なるEML4-ALK変異variantを証明できた一例2010

    • Author(s)
      元井紀子, 他
    • Organizer
      第158回日本肺癌学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-26
  • [Book] Prevention Cancer Report 2010, Tuncer MA(ed) New Hope in Health Foundation, Turkey2010

    • Author(s)
      Inamura K, Ishikawa Y. Lung Cancer
    • Total Pages
      202-4
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/laboratory/department/pathology/index.html

URL: 

Published: 2013-07-31  

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