2011 Fiscal Year Final Research Report
Mechanism of tumor specific porphyrin accumulation after administration of aminolevulinic acid
| Project/Area Number |
22700910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor diagnosis
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
OGURA Shun-ichiro 東京工業大学, フロンティア研究機構, 特任准教授 (90343160)
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| Project Period (FY) |
2010 – 2011
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| Keywords | がんの個性診断 / バイオマーカー |
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| Research Abstract |
Recently, aminolevulinic acid-based photodynamic therapy(ALA-PDT) is being widely used in cancer therapy owing to the tumor-specific accumulation of photosensitizing protoporphyrin IX(PpIX) after the administration of ALA. In the present study, by focusing on genes involved in the porphyrin biosynthesis pathway, we aimed to explore biomarkers that are predictive for the efficacy of ALA-PDT. We found that high expression of the peptide transporter PEPT1(ALA influx transporter) and low expression of the ATP-binding cassette transporter ABCG2(porphyrin efflux transporter) determined ALA-induced PpIX production and cellular photosensitivity in vitro. Thus, it is suggested that PEPT1 and ABCG2 are potential biomarkers to predict the selective porphyrin accumulation after ALA administration.
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Research Products
(45 results)
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[Journal Article] The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver2011
Author(s)
Shun-ichiro Ogura, Kouji Maruyama, Yuichiro Hagiya, Yuta Sugiyama, Kyoko Tsuchiya, Kiwamu Takahashi, Fuminori Abe, Kenji Tabata, IchiroOkura, Motowo Nakajima, Tohru Tanaka
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Journal Title
BMC Research Notes
Volume: 4
Pages: 66
Peer Reviewed
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[Journal Article] Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.2010
Author(s)
Keiichi Ohshima, Kanako Inoue, Akemi Fujiwara, Keiichi Hatakeyama, Kaori Kanto, Yuko Watanabe, Koji Muramatsu, Yorikane Fukuda, Shun-ichiro Ogura, Ken Yamaguchi, Tohru Mochizuki
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Journal Title
PLoS ONE
Volume: 5
Pages: e13247
Peer Reviewed
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