2011 Fiscal Year Final Research Report
The effect of Notch signaling on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma
| Project/Area Number |
22700912
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子標記治療 / ヒト悪性中皮腫 |
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| Research Abstract |
In vitro, Delta-like 4-selective neutralizing antibody treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines, which was accompanied by an increase in phosphor-p53 levels. These effects partly involved induction of growth arrest to MM cells. In vivo, treatments with Delta-like 4-selective neutralizing antibody andγ-secretase inhibitor (an inhibition of Notch signaling)not significantly decreased the growth rate of MM. Finally, Delta-like 4-selective neutralizing antibody treatment also not significantly extended survival interval in an implant animal model of MM.
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Research Products
(2 results)
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[Journal Article] Adiponectin pathway attenuates malignant mesothelioma cell growth2011
Author(s)
Kaijun Niu, Masanori Asada, Tatsuma Okazaki, Shinsuke Yamanda, Takae Ebihara, Hui Guo, Dongying Zhang, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, and Satoru Ebihara
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Journal Title
Am J Respir Cell Mol Biol
Volume: (in press)
DOI
Peer Reviewed
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