Approach for prevention of metastasis of small cell lung cancer by targeting a specific splicing isoform of CADM1

2011 Fiscal Year Final Research Report

• Project/Area Number: 22700914
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Clinical oncology
• Research Institution: The University of Tokyo
• Principal Investigator: IWAI Miwako 東京大学, 医科学研究所, 技術専門職員 (50396884)
• Project Period (FY): 2010 – 2011
• Keywords: 小細胞肺癌・細胞接着因子・CADM1 / スプライシングバリアント・癌転移

Research Abstract

Small cell lung cancer(SCLC) is one of the most malignant cancers that metastasize to the distal organs even in its early stages. We examined the molecular mechanism underlying the malignant growth and metastasis of SCLC to identify candidate molecules targeting SCLC. The exogenous expression of CADM1 enhanced tumorigenicity of SCLC cells in nude mice, suggesting that the expression of CADM1 promotes malignant growth and metastasis of SCLC. Moreover, we found that PI3K and its downstream molecules may play roles in the malignant signaling mediated by CADM1 in SCLC.

Research Products

• [Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer (2012)
  • Author(s): Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Masuda T, Tsuda H, Kanai Y, Onizuka M, Sato Y, and Murakami Y
  • Journal Title: Cancer Science Volume: (掲載確定)
  • DOI: DOI:10.1111/j.1349-7006.2012.02277.*equalcontribution
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells (2011)
  • Author(s): Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y
  • Journal Title: Genes to Cells Volume: Vol.16 Pages: 791-802
  • DOI: DOI:10.1111/j.1365-2443.2011.01525.x.
  • Peer Reviewed
• [Journal Article] Aberrant expression of tumor suppressors CADM1 and 4. 1B in invasive lesions of primary breast cancer (2011)
  • Author(s): Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y
  • Journal Title: Breast Cancer Volume: (掲載確定)
  • DOI: DOI:10.1007/s12282-011-0272-7
  • Peer Reviewed
• [Presentation] 乳がんの進展、再発に関わる細胞接着因子CADM1、並びに新規分子標的の解析 (2011)
  • Author(s): 村上善則、高橋由佳、岩井美和子、荒川敦、伊東剛、櫻井美佳、伊藤彰彦、後藤明輝、伊東紀子、江見充、齋藤光江、霞富士雄
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] 膀胱癌における細胞接着分子CADM1、およびCADM4の異常 (2011)
  • Author(s): 川合剛人,後藤明輝、岩井美和子、永田政義、森川鉄平、久米春喜、深山正久、本間之夫、村上善則
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] Dual roles of a cell adhesion molecule, CADM1/TSLC, in oncogenesis (2011)
  • Author(s): 村上善則、永田政義、櫻井美佳、川合剛人、坪井裕見、岩井美和子、増田真里、後藤明輝
  • Organizer: The 3rd CREST-SBM International Conference : Mathematical Methods in Cancer Cell Biology
  • Place of Presentation: 広島大学
  • Year and Date: 2011-06-09