2011 Fiscal Year Final Research Report
Anticancer virotherapy using mutant oncolytic HSV1 vectors regulated multiple pancreatic cancer associated promoters.
| Project/Area Number |
22700917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Hiroshima University |
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Principal Investigator |
FUKUDA Emi 広島大学, 自然科学研究支援開発センター, 研究員 (20403503)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / ウイルス |
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| Research Abstract |
We combined the minimal promoter region of tumor specific markers(hTERT, CEA, Survivin, ERBB2 and DF3) overexpress in the pancreatic tumor and obtained six constructs those have over 20-fold-higher promoter activity than those of full length promoters. These promoter constructs were integrated to Flip-Flop HSV BAC system and generated the recombinant herpes simplex virus. These recombinant viruses were deficient in the potential of cytotoxic activity and were not sufficient level for medical treatment.
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