2011 Fiscal Year Final Research Report
Investigation of gastric cancer chemoprevention after Helicobacter pylori eradication using rodent models
| Project/Area Number |
22700935
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
TOYODA Takeshi 国立医薬品食品衛生研究所, 病理部, 主任研究官 (50443453)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 化学予防 / ヘリコバクター・ピロリ |
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| Research Abstract |
Although eradication therapy of Helicobacter pylori(H. pylori) has been shown to be effective for the prevention of stomach cancer, the prevention method of gastric carcinogenesis after eradication remains to be developed. In this study, we investigated the inhibitory effect of aspirin on gastric cancer after eradication using H. pylori-infected Mongolian gerbil model. We confirmed that MON/Jms strain is susceptible to H. pylori and develops severe chronic gastritis. As the long-term experiment, the MON/Jms gerbils were intra-gastrically infected with H. pylori, treated with chemical carcinogen, eradication at 36th week, and fed diet containing aspirin. Further examinations are planned to examine the chemopreventive effects of aspirin on the incidence of gastric tumor after eradication.
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[Journal Article] TGF-βsynergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth2012
Author(s)
Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y
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Journal Title
J Exp Med
Volume: 209
Pages: 479-494
DOI
Peer Reviewed
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[Journal Article] Undifferentiated sarcoma of the salivary gland in a Mongolian gerbil(Meriones unguiculatus)2011
Author(s)
Toyoda T, Tsukamoto T, Cho YM, Onami S, Takasu S, Shi L, Saito A, Matsuo S, Tatematsu M, Nishikawa A, Ogawa K
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Journal Title
J Toxicol Pathol
Volume: 24
Pages: 173-177
DOI
Peer Reviewed
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[Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging2011
Author(s)
Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Tani T, Watanabe H, Tanaka T, Hirota K, Inoue M, Tsukamoto T, Toyoda T, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S
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Journal Title
PLoS ONE
Volume: 6
Pages: e26640
DOI
Peer Reviewed
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