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2011 Fiscal Year Final Research Report

Activation mechanism and physiological role of the ATM checkpoint kinase in response to oxidative stress

Research Project

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Project/Area Number 22710052
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionKanazawa University

Principal Investigator

KOBAYASHI Masahiko  金沢大学, がん進展制御研究所, 助教 (70285633)

Project Period (FY) 2010 – 2011
Keywords応答 / ATM
Research Abstract

The sulfhydryl-reactive oxidative stress agents 15d-PGJ_2, ONE and 8-nitro-cGMP induce phosphorylation and accumulation of p53 and apoptosis but DNA damage response. The ATM activation by 15d-PGJ_2 does not require a disulfide-cross-linked dimer formation of ATM, unlike the case by hydrogen peroxide. 15d-PGJ_2 affects the ATM-dependent metabolic regulation. These results obtained in this study characterize the mechanism of the ATM-dependent oxidative stress response that is different from DNA damage response and indicate involvement of the oxidative stress response in regulation of the metabolic system.

  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] ATR-ATRIP kinase complex triggersactivation of the Fanconi anemia DNA repair pathway2012

    • Author(s)
      Shigechi T, Tomida J, Sato K, Kobayashi M, Eykelenboom JK, Pessina F, Zhang Y, Uchida E, Ishiai M, Lowndes NF, Yamamoto K, Kurumizaka H, Maehara Y, Takata M
    • Journal Title

      Cancer Res

      Volume: 72 Pages: 1149-1156

    • DOI

      DOI:10.1158/0008-5472.CAN-11-2904

    • Peer Reviewed
  • [Journal Article] Functional relationshipbetween Claspin and Rad172011

    • Author(s)
      Yoshimura A, Akita M, Hosono Y, Abe T, Kobayashi M, Yamamoto K, Tada S, Seki M, Enomoto T
    • Journal Title

      Biochem BiophysRes Commun

      Volume: 414 Pages: 298-303

    • DOI

      DOI:10.1016/j.bbrc.2011.09.037

    • Peer Reviewed
  • [Journal Article] Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis2010

    • Author(s)
      Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, and Heierhorst J
    • Journal Title

      PLoS Genetics

      Volume: 6 Pages: e1001170

    • DOI

      DOI:10.1371/journal.pgen.1001170

    • Peer Reviewed
  • [Presentation] DNA複製チェックポイントにおけるNBS1の役割2011

    • Author(s)
      小林昌彦,林直之,山本健一
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
  • [Presentation] Arole for NBS1 in ATR activation2011

    • Author(s)
      Kobayashi M, Hayashi N, Yamamoto K
    • Organizer
      日本分子生物学会・第11回春季シンポジウム・金沢国際がん生物学シンポジウム
    • Place of Presentation
      KKRホテル金沢(石川県)
    • Year and Date
      2011-05-26
  • [Presentation] SH基反応性代謝産物によるATMの活性化2010

    • Author(s)
      小林昌彦,林直之,山本健一
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪府)
    • Year and Date
      2010-09-22
  • [Presentation] Arole for NBS1 in ATR activation, Molecular and Cellular Targets for Cancer, Infectious Diseases and Regeneration2010

    • Author(s)
      Kobayashi M, Hayashi N, Yamamoto K
    • Organizer
      The Joint Symposium of the 5th International Symposium of Institute Network and The International Symposium Commemorating Inauguration of Kanazawa University Cancer Research Institute
    • Place of Presentation
      KKRホテル金沢(石川県)
    • Year and Date
      2010-06-24

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Published: 2013-07-31  

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