2011 Fiscal Year Final Research Report
The role of DNA repair factor FNACD2 in centrosome duplication maintenance
| Project/Area Number |
22710054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIMADA Mikio 京都大学, 放射線生物研究センター, 研究員 (20548557)
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| Project Period (FY) |
2010 – 2011
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| Keywords | DNA修復 / 中心体 / 発癌 |
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| Research Abstract |
Centrosome is an organelle function as microtubules organizing center. Disfunction of centrosome results in improper cell division and chromosome unstability leads to tumorigenesis. FANCD2 is a cause gene of Fanconi Anemia, which represent predisposition malignancy. In this study, we addressed the role of FNACD2 in centrosome maintence. Defect of FANCD2 by siRNA knockdown in U2OS cells result in centrosome overduplication and reducing of mictorubule assembly function. These results indicated that FANCD2 is involved in centrosome functions.
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[Journal Article] Regulation of homologous recombination by RNF20-dependent H2B ubiquitination2011
Author(s)
Kyosuke Nakamura, Akihiro Kato, Junya Kobayashi, Shunichi Sakamoto, Douglas V. N. P. Oliveira, Mikio Shimada, Hiromi Yanagoihara, Hiroshi Tauchi, Hidekazu Suzuki, Satoshi Tashiro, Lee Zou, Kenshi Komatsu
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Journal Title
Molecular Cell
Volume: 42
Pages: 515-528
DOI
Peer Reviewed
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