2012 Fiscal Year Final Research Report
Comprehensive analyses of the nucleotide excision repair (NER) molecular mechanisms
| Project/Area Number |
22710056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
OGI Tomoo 長崎大学, 医歯薬学総合研究科, 准教授 (80508317)
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| Project Period (FY) |
2010 – 2012
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| Keywords | DNA修復 / 放射線DNA損傷 / 突然変異 / 発がん |
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| Research Abstract |
Nucleotide excision repair (NER) is a versatile DNA repair system. SiRNA-screening and next generation DNA sequencing were performed to identify novel NER factors. We found that the UVSSA gene (formerly known as KIAA1530) is involved in the transcription-coupled nucleotide-excision repair (TC-NER). The UVSSA protein interacts with TC-NER machinery and facilitates ubiquitination of RNA polymerase IIo stalled at DNA damage sites.
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[Journal Article] Malfunction of the ERCC1/XPF endonuclease results in diverse clinical manifestations and causes three nucleotide excision-repair-deficient disorders, Cockayne Syndrome, xeroderma pigmentosum and Fanconi Anemia2013
Author(s)
Kashiyama K, Nakazawa Y, Pilz D, Guo C, Shimada M, Sasaki K, Fawcett H, Wing J, Lewin S, Carr L, Yoshiura K, Utani A, Hirano A, Yamashita S, Greenblatt D, Nardo T, Stefanini M, McGibbon D, Sarkany R, Fassihi H, Takahashi Y, Nagayama Y, Mitsutake N, Lehmann AR, and *Ogi T
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Journal Title
American Journal of Human Genetics
Volume: 92
Pages: 1-13
DOI
Peer Reviewed
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[Journal Article] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair2012
Author(s)
Nakazawa Y, Sasaki K, Mitsutake N, Matsuse M, Shimada M, Nardo T, Takahashi Y, Ohyama K,Ito K, Mishima H, Nomura M, Kinoshita A, Ono S, Takenaka K, Masuyama R, Kudo T, Slor H, Utani A, Tateishi S, Yamashita S, Stefanini M, Lehmann A, Yoshiura K, and *Ogi T
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Journal Title
Nature Genetics
Volume: 44
Pages: 586-592
DOI
Peer Reviewed
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[Journal Article] Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel syndrome2012
Author(s)
*Ogi T , Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd P, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart G, Taylor M, O'Driscoll M, and Jeggo P
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Journal Title
PLoS Genetics
Volume: 8
Pages: e1002945
DOI
Peer Reviewed
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