2011 Fiscal Year Final Research Report
Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.
| Project/Area Number |
22710067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TACHIBANA Ken 東京理科大学, 薬学部, 助教 (10400540)
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| Project Period (FY) |
2010 – 2011
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| Keywords | トキシコロジー / DNAメチル化 / 環境 / 衛生 / エピジェネティクス / ディーゼル排ガス |
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| Research Abstract |
Diesel exhaust(DE) was exposed to pregnant mice and genomic DNA was obtained from offspring. Subsequently, genome-wide DNA methylation analysis was performed. The results indicated that prenatal DE exposure disrupts the construction of DNA methylation pattern in the brain of offspring. It is also suggested that disrupted DNA methylation pattern is sustained during growth. Our findings provide the important information to clarify the effects and mechanisms of functional impairment of the brain induced by prenatal DE exposure.
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Research Products
(6 results)
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[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
Author(s)
Sunayama J, Sato A, Matsuda K, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C.
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Journal Title
Stem Cells
Volume: Vol.29
Pages: 1327-1337
Peer Reviewed
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