2012 Fiscal Year Final Research Report
Design of Stimuli-Responsive Particles with Tunable Enzymatic Activity
| Project/Area Number |
22710097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHII Haruyuki 東北大学, 大学院・工学研究科, 助教 (80565820)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 中空シリカ粒子 / ベシクル / 酵素様活性 / 無機ナノ粒子 / 温度応答性ゲル |
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| Research Abstract |
Inorganic nanoparticles with enzyme-like activity were deposited on thermo-responsive particles that are vesicle-including hollow silica particles or polymer gel particles. Silica coating of vesicles was first examined and solution pH affected the morphology of silica shell. Gold and ceria nanoparticles were then adsorbed on the vesicles, followed by the silica coating. As-synthesized composite particles can be used as biosensors and catalysts with enzyme-like activity. Platinum nanoparticles were deposited on the poly(N-isopropylacrylamide) gel particles with in situ method and the composite particle showed catalase-like enzymatic activity.
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