2012 Fiscal Year Final Research Report
Investigation on Newly Synthetic Pulmonary Surfactant Incorporated by Fluorinated Amphiphiles
| Project/Area Number |
22710106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Osamu 長崎国際大学, 薬学部薬学科, 教授 (10117129)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 表面・界面物性 / 複合材料 / 肺サーファクタント / ナノ医薬 / 超薄膜 |
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| Research Abstract |
The model peptide in our pulmonary surfactant preparations changes its secondary structure from α-helix to β-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to be prevented from the spectroscopic aspect.
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