Fundamental studies on application of carbon nanotubes to oral drug delivery for the treatment of bowl diseases

2011 Fiscal Year Final Research Report

• Project/Area Number: 22710112
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: NAKAMURA Maki 独立行政法人産業技術総合研究所, ナノチューブ応用研究センター, 産総研特別研究員 (00568925)
• Project Period (FY): 2010 – 2011
• Keywords: ナノ材料 / 機能性材料 / カーボンナノホーン / 経口投与 / 薬物送達 / 腸疾患治療

Research Abstract

Carbon nanotubes are nanometer-sized carbon materials, which are expected to be applicable to drug carriers of drug delivery systems. In mice experiment, orally-administered carbon nanotubes were not absorbed from the gastrointestinal tract, and excreted in feces, suggesting that neither accumulation of orally-administered carbon nanotubes in body nor associated toxicity would be observed. These results indicated that carbon nanotubes could be riskless oral drug carriers in drug therapy of inflammatory bowel diseases.

Research Products

• [Journal Article] Single-walled carbon nanohorns as drug carriers : adsorption of prednisolone and anti-inflammatory effects on arthritis (2011)
  • Author(s): 中村真紀、田原善夫、池原譲、村上達也、土田邦博、飯島澄男、和賀巌、湯田坂雅子
  • Journal Title: Nanotechnology Volume: vol.22 Pages: 465102
  • URL: http://iopscience.iop.org/0957-4484/22/46/465102
  • Peer Reviewed
• [Presentation] カーボンナノホーンの薬剤キャリアへの応用 (2011)
  • Author(s): 中村真紀、田原善夫、池原譲、村上達也、土田邦博、飯島澄男、和賀巌、湯田坂雅子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 20110300
• [Presentation] ナノホーンのドラッグキャリアへの応用-プレドニゾロンの担持と関節炎への抗炎症作用 (2010)
  • Author(s): 中村真紀、田原善夫、村上達也、土田邦博、飯島澄男、和賀巌、湯田坂雅子
  • Organizer: 第39回フラーレン・ナノチューブ総合シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20100900
• [Book] カーボンナノチューブ・グラフェンハンドブック (2011)
  • Author(s): 中村真紀、張民芳、湯田坂雅子
  • Total Pages: 75-77
  • Publisher: コロナ社