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2011 Fiscal Year Final Research Report

Development of a cell microarray chip device for diagnosis of infectious disease

Research Project

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Project/Area Number 22710124
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Microdevices/Nanodevices
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

YAMAMURA Shohei  独立行政法人産業技術総合研究所, 健康工学研究部門, 研究員 (50432141)

Project Period (FY) 2010 – 2011
Keywords細胞チップ / マイクロアレイ / バイオチップ / 単一細胞解析 / ハイスループットスクリーニング / 感染症 / マラリア
Research Abstract

Malaria is a vector-borne infectious disease caused by protozoan parasites. There are approximately 500 million cases of malaria, killing over two million people each year. The most standard detection method ; Giemsa-stained blood smears to detect malaria parasite in erythrocytes is time-consuming and need to technical handling. Although the detection methods based on immunochromatography and PCR were developed, they also have some problems in sensitivity and rapidity. In this study, we have developed a novel cell microarray system to detect malaria-infected erythrocytes with the high-sensitivity(<0.0001%) in a short time.

  • Research Products

    (14 results)

All 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Accurate detection of carcinoma cells by use of a cell microarray chip2012

    • Author(s)
      Yamamura S, Yatsushiro S, Yamaguchi Y., Abe K., Shinohara Y., Tamiya E., Baba Y., Kataoka M.
    • Journal Title

      PloS One

      Volume: 7 Pages: e32370

    • DOI

      DOI:10.1371/journal.pone.0032370

    • Peer Reviewed
  • [Journal Article] Development of a cell microarray chip for detection of circulating tumor cells2012

    • Author(s)
      Yamamura S, Yatsushiro S, Abe K, Baba Y, Kataoka M.
    • Journal Title

      J. Phys. Conf. Ser.

      Volume: 352 Pages: 12041

    • DOI

      DOI:10.1088/1742-6596/352/1/012041

    • Peer Reviewed
  • [Journal Article] Ribonuclease protection assay on microchip electrophoresis2011

    • Author(s)
      Yamaguchi Y, Yatsushiro S, Yamamura S, Abe H., Abe K., Watanabe M., Kajimoto K., Shinohara Y., Baba Y., Kataoka M.
    • Journal Title

      Analyst

      Volume: 136 Pages: 2247-2251

    • DOI

      DOI:10.1039/c0an01044h

    • Peer Reviewed
  • [Journal Article] Rapid and Highly Sensitive Detection of Malaria-Infected Erythrocytes Using a Cell Microarray Chip2010

    • Author(s)
      Yatsushiro S, Yamamura S, Yamaguchi Y, Shinohara Y, Tamiya E, Horii T, Baba Y, Kataoka M
    • Journal Title

      PloS One

      Volume: 5 Pages: e13179

    • DOI

      DOI:10.1371/journal.pone.0013179

    • Peer Reviewed
  • [Journal Article] 細胞チップを用いた細胞の機能解析および診断システムの開発2010

    • Author(s)
      山村昌平,八代聖基,山口裕加,民谷栄一,片岡正俊
    • Journal Title

      電気学会論文誌C

      Volume: 130 Pages: 1795-1799

    • DOI

      DOI:10.1541/ieejeiss.130.1795

    • Peer Reviewed
  • [Presentation] 生活習慣病の診断用マイクロチップ、ヘルスケア・イノベーションフォーラム(HCIF)2011

    • Author(s)
      山村昌平、阿部佳織、八代聖基、片岡正俊
    • Organizer
      第11回事例研究部会(招待講演)
    • Place of Presentation
      香川県
    • Year and Date
      2011-11-25
  • [Presentation] Development of a cell microarray chip for detection of circulating tumor cells2011

    • Author(s)
      Yamamura S, Yatsushiro S, Abe K, Baba Y, Kataoka M
    • Organizer
      The Asia-Pacific Interdisciplinary Research Conference 2011(AP-IRC 2011)
    • Place of Presentation
      愛知県
    • Year and Date
      2011-11-18
  • [Presentation] Quantitative analysis of serum interleukin-6 by immunoassay on microchip2011

    • Author(s)
      Abe K, Yatsushiro S, Yamamura S, Tanaka M, Ooie T, Baba Y, Kataoka M
    • Organizer
      The Asia-Pacific Interdisciplinary Research Conference 2011(AP-IRC 2011)
    • Place of Presentation
      愛知県
    • Year and Date
      2011-11-17
  • [Presentation] 各種疾患診断を目指した細胞チップの開発2011

    • Author(s)
      山村昌平
    • Organizer
      第3回若手異分野連携体セミナー(招待講演)
    • Place of Presentation
      岡山県
    • Year and Date
      2011-07-15
  • [Presentation] 細胞チップを用いた感染症迅速診断法の開発2011

    • Author(s)
      山村昌平、八代聖基、山口裕加、片岡正俊
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-03-28
  • [Presentation] Cell microarray chip for rapid and highly sensitive detection of malaria-infected erythrocytes2011

    • Author(s)
      Yamamura S, Yatsushiro S, Yuka Yamaguchi, Kataoka M
    • Organizer
      The 5^<nd> International Workshop on Approaches to Single-cell Analysis
    • Place of Presentation
      東京都
    • Year and Date
      2011-03-04
  • [Presentation] Rapid and highly sensitive detection system for malaria parasite with a cell microarray chip2010

    • Author(s)
      Yatsushiro S, Yamamura S, Kataoka M
    • Organizer
      The 3rd Stakeholders Meeting of the African Network for Drugs and Diagnostics Innovation(ANDI)
    • Place of Presentation
      Kenya(Nairobi)
    • Year and Date
      2010-10-11
  • [Presentation] 細胞チップを用いたマラリア原虫迅速検出手法の構築2010

    • Author(s)
      八代聖基、山村昌平、山口裕加、堀井俊宏、片岡正俊
    • Organizer
      第51回日本生化学会中国四国支部会
    • Place of Presentation
      山口県
    • Year and Date
      2010-05-14
  • [Remarks]

    • URL

      http://unit.aist.go.jp/hri/group/barg/

URL: 

Published: 2013-07-31  

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