2011 Fiscal Year Final Research Report
Development of label-free biochip for early diagnosis of Alzheimer's disease using artificial nano-receptor particles
| Project/Area Number |
22710125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
FUCHIWAKI Yusuke 独立行政法人産業技術総合研究所, 健康工学研究部門, 研究員 (80468884)
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| Project Period (FY) |
2010 – 2011
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| Keywords | バイオチップ |
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| Research Abstract |
We studied to develop a novel label-free biochip device for early diagnosis of Alzheimer's disease using molecularly imprinted-based artificial receptors. In order to improve the nonspecific adsorption on surface of nano-artificial receptors, the newly functional polymer, which includes both phophorylcholine and amino groups, was synthesized and accomplished to increase signal to noise ratio. Ink-jet printing technology has been included for the accurate preparation of bio-recognition interface, and got in about three times lower variations from calibration curves as compared to previous studies.
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