2011 Fiscal Year Final Research Report
Deleterious effect to human genes by meiotic recombination
| Project/Area Number |
22710190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical genome science
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| Research Institution | Tohoku University |
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Principal Investigator |
MAKINO Takashi 東北大学, 大学院・生命科学研究科, 助教 (20443442)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 相同組替え |
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| Research Abstract |
The results in this study suggest that those functional regions of the human genome which are subject to high recombination rates may experience an elevated rate of deleterious point mutation and hence are more likely to become implicated in inherited disease, particularly in the case of those diseases that are caused by rare genomic variants.
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