2011 Fiscal Year Final Research Report
Synthesis of novel inhibitors of hypoxia-inducible factor-1 transcriptional pathway based on natural products
| Project/Area Number |
22710223
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Yokohama City University (2011)
Keio University (2010) |
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Principal Investigator |
ISHIKAWA Yuichi 横浜市立大学, 国際総合科学部, 助教 (40348826)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 構造活性相関 |
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| Research Abstract |
Synthesis of strongylophorine analogues, inhibitors of hypoxia-inducible factor-1(HIF-1) transcriptional pathway, was attempted. Considering the structure of strongylophorines, synthesis of analogue possessing a distinctive lactone structure commenced with cholesterol, easily available steroid compound. The efforts of functionalization against cholesterol derivatives provided the desired analogue.
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