2011 Fiscal Year Final Research Report
Development of the cell morphology database for drug and bioprobe discovery
| Project/Area Number |
22710228
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUTAMURA Yushi 独立行政法人理化学研究所, 化学情報・化合物創製チーム, 特別研究員 (70525857)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞形態変化 / ハイコンテントスクリーニング |
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| Research Abstract |
To discover small drug like molecules, we have constructed the encyclopedia of cellular morphology, consisting of the cell-shape changes induced by various compounds. Particularly, we have developed high-content image analysis method to examine the effect of～ 100 routinely used chemicals on the cell morphology accompanied by statistical characterization of the obtained phenotypic data. We demonstrated the cell morphology-based profiling system not only reproduces "drug-target-phenotype" relationships for a series of drugs with known targets but also raises the possibility to clear the way to discovery of unique drug candidates.
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