2012 Fiscal Year Final Research Report
Development and application of fluorine-based photoaffinity probe
| Project/Area Number |
22710229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo University of Science (2011-2012)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 光親和性標識 / 標的タンパク質 |
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| Research Abstract |
In this study, we have demonstrated development of novel photoaffinity labeling, in which 4-fluoroindole was utilized as a photoreactive group. Model study revealed that Neutravidin photolabeled with biotinylated 4-fluorotryptophan could be detected. This method is expected to be applied for identification of receptor proteins for peptide ligand
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