2011 Fiscal Year Final Research Report
Effective prevention and control of cholera using LAMP method
| Project/Area Number |
22710252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Area studies
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| Research Institution | Osaka University |
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Principal Investigator |
OKADA Kazuhisa 大阪大学, 微生物病研究所, 特任助教 (40420434)
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| Project Period (FY) |
2010 – 2011
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| Keywords | Vibrio cholerae / コレラ流行制御 |
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| Research Abstract |
Using the rapid gene detection method(LAMP) for cholera toxin gene, it was possible to identify cholera-infected persons(48 positive cases out of 619 subjects) in remote area of Thailand. We reported these findings to the local public health office, and local medical officers provided medicine with the residents showing positive reaction as a quick countermeasure. It turned out to be effective in suppressing cholera from the area. Our molecular epidemiology studies of V. cholerae O1 isolates provide insight into the genetic background and divergence of recent isolates in Thailand and other Asian countries. Results also showed the emergence, year-long survival, and disappearance of particular isolates spatially and temporally. These contribute to a strategy for the prevention and control of cholera outbreaks.
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