2012 Fiscal Year Final Research Report
Psycho physiological study for the cholinergic input involved the formational, maintainable and mnemonic function of the hippocampal related networks
| Project/Area Number |
22730583
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental psychology
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| Research Institution | Hiroshima University (2011-2012)
Fukushima Medical University (2010) |
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Principal Investigator |
OKADA Kana 広島大学, 総合科学研究科, 特任助教 (50528263)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生理 |
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| Research Abstract |
Many investigations into Alzheimer’s disease reveal the relatively early and substantial loss of cholinergic neurons, followed neurodegenerative abnormalities, as well as the severe impairment in cognition and memory. This study aimed the generation and assessment of animal model of Alzheimer’s disease in mice with memory deficiency and the examination about the effect of the drugs and neurodegenerative abnormalities along the cholinergic deficiency on memory impairment of the model. This study exhibited that the mouse with cholinergic ablation in basal forebrain might be a reliable animal model of Alzheimer’s disease and that there was the efficient drug for the memory recovery in the model mouse.
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[Presentation] Behavioral assessment of the deficiency in cholinergic interneuron of rats, for the consideration of cognitive flexibility2010
Author(s)
Okada, K., Kai, N., Shiota, A., Ueda, M., Tsutsui, Y., and Kobayashi, K
Organizer
the XVIIIth International Workshop on Genetic Systems in the Rat in 2010
Place of Presentation
Kyoto
Year and Date
20101130-1203
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