2011 Fiscal Year Final Research Report
Development of polymer immobilized metal nanocluster catalysts toward efficient one-pot tandem synthetic reactions
| Project/Area Number |
22750032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 固相触媒 / 金 / ワンポット反応 / エステル / アミド / 酸素酸化 / ナノクラスター |
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| Research Abstract |
We have already developed gold nanocluster and bimetallic cluster catalysts immobilized on polystyrene-based polymer(PI-Au, PI-Au/M) and on carbon black-stabilized polymer(PI/CB-Au, PI/CB-Au/M), and found that these catalysts mediated aerobic oxidation of alcohols and so on. In this research, we have newly developed direct oxidative ester formation reactions from alcohols and one-pot aerobic oxidation-Michael reaction between allylic alcohols and 1, 3-dicarbonyl compounds. We have also realized aerobic oxidative amidation reaction from alcohols and amines using newly developed bimetallic catalysts of gold and iron-group metals(PI/CB-Au/Ni,-Au/Co,-Au/Fe). In addition, we have developed oxidative benzoxazole and benzothiazole synthesis from Schiff bases composed of o-aminophenols and aldehydes. These heterocycles could be obtained from N-alkyl-o-aminophenols through three step reactions including two aerobic oxidation steps in one-pot.
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