2012 Fiscal Year Final Research Report
Development of Environmentally Benign Biaryl Couplings Based on Nickel Catalysts
| Project/Area Number |
22750040
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Organic chemistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
HIRANO Koji 大阪大学, 大学院・工学研究科, 助教 (70532696)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 有機合成化学 / 有機金属化学 / ニッケル / 銅 / ホウ素 / ケイ素 / アリール化 / 炭素-水素結合直接変換 |
|---|
| Research Abstract |
We have developed nickel-catalyzed oxidative direct biaryl couplings of heteroarenes with arylsilanes and arylboronic acids via C-H bond cleavage. The above catalysis enables the halogen-free construction of biaryl structures. Relevant new transformations of heteroarenes such as direct alkynylation, allylation, and alkylation were also achieved. Moreover, we succeeded in the copper-mediated dehydrogenative cross-biaryl couplings via two-fold C-H cleavage.
|
