2012 Fiscal Year Final Research Report
Development of Asymmetric Catalysis by Transition Metal Complexes with C-N Bond Axial Chirality
| Project/Area Number |
22750082
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
MINO Takashi 千葉大学, 大学院・工学研究科, 准教授 (40302533)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 不斉配位子 / 有機化学 / 不斉合成 |
|---|
| Research Abstract |
We report here the synthesis of C-N bond atropisomers of N-indole type phosphine ligandand acyclic amines. We also report their application as the chiral ligands for suchcatalytic asymmetric reactions as a palladium-catalyzed asymmetric allylic alkylationof malonate. And more, we report the palladium-catalyzed asymmetric allylic alkylationof indoles with 1,3-diphenyl-2-propenyl acetate using C-N bond axially chiral phosphineligands in good yields with moderate to high enantioselectivities.
|
