2011 Fiscal Year Final Research Report
Development of highly functional asymmetric catalysis and reagents by using coordinative group
| Project/Area Number |
22750089
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | Nagoya Institute of Technology |
|---|
Principal Investigator |
NAKAMURA Shuichi 名古屋工業大学, 大学院・工学研究科, 准教授 (20335087)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 不斉合成 / 反応 |
|---|
| Research Abstract |
In order to develop the synthesis of chiral compounds, we designed novel organocatalysts having a coordinative heteroaryl group in their structures. Although enantioselective aldol reaction to ketone is generally difficult, the reaction using our novel organocatalysts afforded good results. Especially, biologically active flustraminol and AG-041R derivatives can be prepared by using the organocatalysts. Furthermore, organocatalyst could be readily reusable without significant loss of catalytic activity or enantioselectivity.
|
