2011 Fiscal Year Final Research Report
Contamination and ecotoxicological variation by preservative originating from pharmaceutical and cosmetic products in aquatic environment
| Project/Area Number |
22750140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental chemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 水環境 / 環境動態 / 発生源 / 塩素化副生成物 / 光変換生成物 / 構造決定 / 受容体原性毒性 |
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| Research Abstract |
This study was conducted to examine the contaminant levels of parabens and their secondary products, whose presence in the aquatic environment has not yet been investigated. First, we have developed a method for the simultaneous analysis of 23 parabens and related compounds. The analysis results indicate that chlorinated derivatives preferentially partition to the suspended-solid phase in river water. With regard to the sources of chlorinated derivatives, chlorination tests with tap water revealed that the paraben was immediately chlorinated to yield the dichlorinated paraben. When an aqueous solution of the chlorinated paraben was irradiated with an ultraviolet light, chlorinated catechol was indentified and revealed to be rather resistant to photochemical decomposition. In the toxicity assessment with several hormone receptor mediated reporter assays, the activity of the retinoic acid receptor of a chlorinated propyl paraben is considerably higher than that of the corresponding parent paraben.
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