2011 Fiscal Year Final Research Report
Nanoarraying of Proteins on DNA Nanostructures and Single-Molecule Observation of Enzymes
| Project/Area Number |
22750144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kansai University (2011)
The University of Tokyo (2010) |
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Principal Investigator |
KUZUYA Akinori 関西大学, 化学生命工学部, 准教授 (00456154)
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| Project Period (FY) |
2010 – 2011
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| Keywords | DNA / DNAナノ構造体 / 単分子解析 |
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| Research Abstract |
We have developed versatile sensing systems for a variety of chemical and biological targets at molecular resolution. We have designed functional nanomechanical DNA origami devices that can be used as "single-molecule beacons", which consist of two levers approximately 170 nm long connected at a fulcrum. Various single-molecule inorganic/organic targets ranging from metal ions to proteins can be visually detected on AFM by a shape transition of the origami devices.
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Research Products
(17 results)
