2012 Fiscal Year Final Research Report
Synthesis and biological activity of cyclic diadenylic acid and its derivatives
| Project/Area Number |
22750148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 天然物有機化学 / 環状ジアデニル酸 |
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| Research Abstract |
We established a practical synthesis of cyclic bis(3'-5')diadenylic acid (c-di-AMP), which was recently identified as a second messenger monitoring DNA integrity during sporulation in the soil bacterium Bacillus subtilis. Using the synthetic c-di-AMP obtained by ourmethod, we revealed that c-di-AMP promotes the cell division of Chlamydomonas reinhardtii, a kind of freshwater green algae. The three 2'-modified c-di-AMPs synthesized by our method were also found to enhance the cell division.
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