2012 Fiscal Year Final Research Report
Synthetic Study of A Heterocyclic Molecular Motor Toward DNA Conformational Change
| Project/Area Number |
22750159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子マシン / 分子モーター / DNA / 光スイッチ |
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| Research Abstract |
We have designed a new heterocyclic molecular motor 2, which would intercalate in the DNA and induce conformational change of the DNA structure. Heterocyclic molecular motors (±)-trans-8and (±)-cis-8were prepared by the McMurry coupling and Buchwald-Hartwig reaction of heterocyclic ketone (±)-7d. The relative stereochemistry of (±)-trans-8and (±)-cis-8was determined as (2R*,2'R*)-(P*,P*) by X- ray crystallography. CD spectral titration experiments exhibit that significant conformational changes of B-DNA are not induced by (±)-trans-10and (±)-cis-10.
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