• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Regeneration of a large-scale and higher-order structural tissue using mesenchymal stem cells under culturing technique of heterogeneous mechanical circumstance

Research Project

  • PDF
Project/Area Number 22760073
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Materials/Mechanics of materials
Research InstitutionNagoya University

Principal Investigator

MORITA Yasuyuki  名古屋大学, 工学研究科, 講師 (90380534)

Project Period (FY) 2010 – 2011
Keywords間葉系幹細胞 / 腱細胞・腱組織 / 細胞外マトリックス / コラーゲンネットワーク / 機械的伸縮刺激 / 細胞配列・配向 / ひずみ勾配 / 許容限界軸ひずみ
Research Abstract

The following conclusions were obtained in this study. When mesenchymal stem cells(hBMSCs) were subjected to uniform stretching as mechanical stimulation, there was different strain relativity between amounts of protein synthesis, based on the extracellular matrix, and the tissue structuralization. In addition, an allowable limit axial strain of hBMSCs which directly related to the cell alignment behavior, was elucidated simply and precisely using heterogeneous strain stimulation technique. The axial strain value was 5. 1% in the tensile stimulation. Furthermore, synthesis curve of respective proteins was strongly dependent upon the stretch ratio. Type I collagen synthesis indicated broadband responsiveness in terms of the stretch ratio.

  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Experimental study on displacement and strain distributions of bone model with dental implant2011

    • Author(s)
      Y. Morita, Y. Matsushita, M. Todo, and K. Koyano
    • Journal Title

      Applied Mechanics and Materials

      Volume: 83 Pages: 73-77

    • Peer Reviewed
  • [Journal Article] デジタル画像相関法による骨セメント型人工股関節を模擬したステム/骨セメント/皮質骨界面周辺の微視的変形挙動計測2011

    • Author(s)
      森田康之
    • Journal Title

      実験力学

      Volume: 11(2) Pages: 107-11

    • Peer Reviewed
  • [Journal Article] Experimental evaluation of strain distribution in alveolar bone model around dental implant determined via DIC2011

    • Author(s)
      Y. Morita, M. Todo, Y. Matsushita, and K. Koyano
    • Journal Title

      Proc. of KSME 2012 Bio Engineering Division Spring Conference

  • [Journal Article] Shrinkage analysis of a light-cured composite resin in cavity by X-ray CT images2010

    • Author(s)
      K. Arakawa, T. Furukawa, Y. Morita, M. Uchino, and H. Kaida
    • Journal Title

      Journal of JSEM

      Volume: 10(Special Issue) Pages: 229-233

    • Peer Reviewed
  • [Journal Article] Deformation measurement of bone model with a dental implant by DIC2010

    • Author(s)
      Y. Morita, Y. Matsushita, M. Todo, and K. Koyano
    • Journal Title

      Proc. International Workshop on Nano, Bio and Amorphous Materials

  • [Presentation] Experimental evaluation of strain distribution in alveolar bone model around dental implant determined via DIC2012

    • Author(s)
      Y. Morita, M. Todo, Y. Matsushita, and K. Koyano
    • Organizer
      KSME 2012 Bio Engineering Division Spring Conference
    • Place of Presentation
      Chonnam National University, Gwangju, Korea
    • Year and Date
      2012-03-29
  • [Presentation] ひずみ勾配を有する伸縮刺激下での幹細胞の培養に関する研究2012

    • Author(s)
      渡邉早智,森田康之,巨陽
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学
    • Year and Date
      2012-01-07
  • [Presentation] 骨髄幹細胞の腱細胞分化および細胞外マトリックス生成に対する伸展刺激の伸展率の影響2011

    • Author(s)
      森田康之,鈴木敏,渡邉早智,巨陽
    • Organizer
      日本実験力学会2011年度年次講演会
    • Place of Presentation
      奈良県文化会館
    • Year and Date
      2011-08-31
  • [Presentation] Experimental study on displacement and strain distributions of bone model with dental implant2010

    • Author(s)
      Y. Morita, Y. Matsushita, M. Todo, and K. Koyano
    • Organizer
      The International Conference on Experimental Mechanics 2010(ICEM2010)
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2010-12-01
  • [Presentation] Deformation measurement of bonemodel with a dental implant by DIC2010

    • Author(s)
      Y. Morita, Y. Matsushita, M. Todo, and K. Koyano
    • Organizer
      International Workshop on Nano, Bio and Amorphous Materials
    • Place of Presentation
      Zao, Miyagi
    • Year and Date
      2010-08-10
  • [Book] Interface Oral Health Science 20112012

    • Author(s)
      Y. Morita, M. Todo, Y. Matsushita, and K. Koyano
    • Total Pages
      137-139

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi